Although IVF has become the best known fertility treatment since its introduction in 1978, in vitro fertilisation is actually one of several assisted conception techniques.

Intracytoplasmic Sperm Injection or ICSI is performed as part of IVF and addresses sperm-related barriers to successful conception. One in 7 UK couples will have difficulties conceiving and it’s estimated that male infertility is a factor in 30 to 50% of cases.

Am I suitable for ICSI?

Intracytoplasmic Sperm Injection is not suitable for all patients undergoing fertility treatment. If male factor infertility has been identified or you have undergone previous unsuccessful IVF cycles, then ICSI may be recommended to improve your chances of conceiving. Issues that ICSI can address:

  • Low sperm count
  • Poor sperm motility
  • Sperm is abnormally shaped
  • There are high levels of antibodies in the semen (antibodies that are produced by the man’s body and may inhibit sperm function)
  • Sperm has been frozen
  • A medical condition or vasectomy means surgical sperm retrieval is required
  • Embryo testing is being performed
  • Previously failed IVF cycles

What happens if we opt for ICSI?

ICSI is performed as part of in vitro fertilisation, so every stage is the same as a conventional IVF treatment, but a different fertilisation technique is used in the laboratory.

To fertilise an egg, the sperm must penetrate the egg to reach the cytoplasm and during conventional IVF, the sperm and egg are mixed in culture media within a petri dish and left to naturally fertilise. However, if the sperm has poor motility, which refers to its ability to move efficiently, or an abnormal shape, then it can fail to push through the hard outer layer.

With ICSI, we select the healthiest sperm and directly inject it into the egg. Embryos are then left to develop as normal while being monitored by our embryologist before the best is chosen for implantation in the womb.

Are there any risks to ICSI?

The risks of ICSI are the same as IVF. The risk of birth defects is slightly higher than of a natural pregnancy but similar to conventional IVF. It is highly likely that males conceived with ICSI may inherit genetic male fertility issues, but research is limited currently as ICSI has only been used since the early 1990s.

What are the success rates of ICSI?

This is one stage of in vitro fertilisation, which can improve the chance of conception with IVF in couples where male factor infertility is an issue. But success rates are still linked to the overall success rate for IVF. The Human Fertilisation and Embryology Authority (HFEA) don’t publish separate statistics for IVF with ICSI.

To find out if you’re suitable for ICSI as part of your IVF treatment, call us on 0203 263 6025 to arrange a consultation at Aria Fertility Clinic.

Almost two years of living with COVID has resulted in ‘heartbreaking’ delays to fertility treatment, according to a survey of nearly 400 patients by the UK’s national fertility charity.

Last week was National Fertility Awareness Week, led by Fertility Network UK, to raise awareness of all aspects relating to fertility, from fair access to NHS-funded treatments, the emotional impact of male infertility, through to encouraging donor donation. The charity also reviewed the devastating impact the COVID pandemic has had on those waiting for fertility treatment.

Although clinics were officially given the green light to resume treating patients in May 2020, the backlog is still affecting many patients receiving fertility treatment through the NHS.

New research found that 58% of respondents had experienced delays being able to access treatment and a quarter had not been able to access counselling. Delays had affected both diagnostic testing, including semen analysis and blood tests, and surgical procedures with interruptions to treatment ranging from months to up to two years. Tests were often out of date and needed repeating.

Going it alone

Another upsetting aspect has been the impact on face-to-face services. In some instances, male partners were unable to attend fertility appointments and often patients had to receive devastating news over the phone.

The impact on mental health

Patients reported increased levels of stress, anxiety and depression as a result of delays. Counselling was also affected with many unable to access emotional support.

Gwenda Burns, chief executive of Fertility Network UK, said: “Our survey shows the devastating reality of delays to tests and treatment for fertility patients. It is clear the delays are ongoing and that many are concerned about how this will impact their chances of having a family. We are particularly concerned for those who haven’t been able to access counselling and would remind anyone affected by this that we are at hand to offer support.

“We are particularly concerned about the impact on fertility patients, where we know that age makes such a difference to outcomes. Time really is of the essence for fertility patients. Research from Aberdeen University earlier this year showed the impact that delays of six months or a year may have, and we know this is now a reality for many patients.”

One result of delays to NHS fertility provision has been more couples or individuals seeking treatment at private clinics.

Aria Fertility Clinic was developed during the height of the pandemic, receiving its license from HFEA in 2021. “We have managed to remain open throughout, providing consultations, investigations and the full range of treatment services, whilst always prioritising the safety of our patients,” Rob Smith, Clinic Director. Find out more about COVID and fertility treatment at Aria or call us on +44 (0) 203 263 6025 to speak to one of the team.

Made in Chelsea star Ollie Locke has revealed his surrogacy heartache on the latest series of the reality TV programme. He had recently announced on Instagram that the first round of IVF that he and his husband Gareth underwent with a surrogate hadn’t worked.

Ollie wrote. “We wanted to share an update with all our amazing supportive followers who have been with us on our surrogacy journey.

“I’m sorry I have been quiet, sadly we found out last week our first attempt at IVF hasn’t worked and after the heartbreaking news we have come to terms with the situation and are now looking forward to getting out to go for a second attempt very soon.”

Celebrity stories – from Ollie to Tom Daley and Kim Kardashian – have brought surrogacy into the spotlight and now a new UK study has shown that the number of parents using surrogates in England and Wales has quadrupled over the last decade.

Increase in parents using surrogates in the UK

Kent University scientists reviewing the data found that 413 parental orders were issued last year, indicating that almost four times as many parents in England and Wales are using surrogates now compared to ten years ago. In a new report published in collaboration with My Surrogacy Journey, a non-profit organisation in the UK supporting surrogates and intended parents, Dr Kirsty Horsey of Kent Law School found more parents were having babies through surrogacy. Research also revealed that two thirds of the applicants were mixed-sex couples in their 30s and 40s.

‘It is great to see such positive reporting on surrogacy in the mainstream media,” Dr Horsey commented, “particularly as the Law Commissions are currently reviewing the law on surrogacy, which I have long argued is out of date and in need of reform. It is to be hoped that reports such as this will feed into public and parliamentary debates on how any new law should look and enable progressive law reform to take place.”

Reality TV star Kim Kardashian opted for surrogacy after suffering placenta accreta, a serious medical condition that can be fatal for mother and child. She has now had two surrogate pregnancies: “I always knew surrogacy was an option — now it’s my reality. Whatever is meant to be will be.”

Celebrities being open about the surrogate experience is one of the driving factors in increased interest in this procedure. Yet, as Ollie Locke and his husband have revealed, surrogacy is not without its challenges.

Get in touch to discuss this in more depth with our fertility experts or read our pages on surrogacy for same-sex and mixed couples.

A new study has revealed that men may not have quite as long as they think to start a family. You may think that the biological clock is something only women need to worry about. However, the findings of this latest study show that there may also be a time limit on male fertility.

So, when can you expect male fertility to start to drop? Let’s look at what the study revealed…

Male fertility starts to drop in the mid-forties

Scientists from the Genea IVF clinic in Australia carried out the latest study, reviewing over 40,000 sperm tests. It was discovered that male fertility starts to drop in the mid-forties. By the age of 55, fertility deteriorates dramatically.

After studying the sperm samples, the two likely causes are reduced sperm mobility and DNA information damage. However, there are a lot of other potential causes too. Understanding the factors that can contribute to poorer male fertility can help you take preventative measures.

Why does male fertility reduce?

There is a vast range of factors that can cause male fertility to reduce. Some of the main things to factor in include:

  • Medical issues
  • Medical and environmental history
  • Lifestyle choices
  • Age

Certain medical issues such as illnesses, chromosomal defects, and anatomical issues, can all impact male fertility. Therefore, if you are experiencing fertility problems, it’s important to check that there isn’t an underlying medical issue.

Your medical and environmental history can also play a role. This includes any medications you might be taking or surgeries you may have undergone in the past. Environmental factors that could impact fertility include overexposure to radiation, industrial chemicals, or heavy metals.

It is also known that modern lifestyles have greatly impacted male fertility. Poor sperm mobility and lower sperm counts are becoming a worrying problem for modern men. This is said to be down to a poor western diet, excessive alcohol use, smoking, and illegal drug use.

Finally, age does play a role in fertility. While they may not experience the same level of age-related fertility issues as women, men still need to be aware of their own risks.

Undergoing a fertility assessment

Due to how prevalent male-related fertility issues are, it is important to test the fertility of both partners when couples are struggling to conceive. At Aria Fertility, we carry out extensive fertility assessments to identify any issues.

A range of tests will be carried out, and the results will be discussed with you to give you a clear picture of your fertility. The male fertility assessment involves looking into your BMI, carrying out a sperm analysis, and screening for infections. Depending upon the results, you may be recommended to undergo more extensive medical tests.

Fertility problems in men are becoming more prevalent in Western society. An Israeli study in 2017 that received a great deal of media attention found that sperm counts among men in the West have more than halved in the past 40 years and were currently falling by 1.4% on average per year.

Couples who are struggling to get pregnant can undergo an extensive fertility assessment to determine the cause and identify potential treatment options. Get in touch to find out more.

Last month, we wrote about managing IVF in the workplace which struck a chord with many of you. One interesting development from the COVID pandemic is that it seems to have accelerated the trend for fertility treatment benefits as employers prioritise employee wellbeing.

We take a look at the fertility treatment benefits starting to be introduced by employers.

What fertility treatments are being offered by employers?

Perks within businesses are certainly nothing new. However, up until now they largely consisted of free gym memberships, company cars, or additional days off.

In recent years, however, employers have started to realise the importance of employee wellbeing. For employees who are going through fertility problems, it can greatly impact their wellbeing and their performance. That is why several UK groups have started to offer fertility-related benefits.

Large UK employers such as NatWest and Clifford Chance, have introduced fertility benefits totalling up to £45,000 per employee. These include offering to pay for IVF or surrogacy. Other benefits include providing time off for appointments, counselling, and miscarriage leave.

Rarely did employers get involved with the outside lives of their workers? So, what’s changed?

The pandemic and its impact on employee wellbeing

Employee wellbeing was already starting to become a priority before COVID hit. However, the toll the pandemic has taken on the population has forced businesses to accelerate their efforts.

There has also been a huge increase in the number of employees leaving their jobs as people revaluate what is important in life. With a record number of job vacancies available, employers are having to pull out all the stops to keep hold of their existing workforce.
According to research, 49% of employers have introduced new benefits for their workers since the pandemic began.

Our contribution to fertility treatment benefits

Aria Fertility works alongside Carrot Fertility to provide fertility benefits to employees through their employers. Flexible plans are available to suit businesses of all sizes. Just some of the benefits companies can opt to include are:

  • Fertility medications
  • Pregnancy support
  • Family planning and care
  • Adoption benefits

The fact businesses are starting to help employees with fertility issues is fantastic. However, it is still only select businesses that have introduced these benefits. As time goes on, more HR professionals are realising the importance of fertility-related benefits. At the very least, workers who are experiencing fertility troubles can ask for more flexible working hours.

There is no denying that fertility issues can greatly impact employee wellbeing and performance. Employers who prioritise their workers mental and physical health such as offering fertility treatments are going to also reap the benefits. Get in touch to find out more.

The government has made a major announcement this week on egg, sperm and embryo freezing limits following a public consultation earlier this year. Currently, the statutory storage restriction is 10 years, but in a landmark ruling, they plan to extend the storage limit to a maximum of 55 years, with 10-year renewals.

Dr Anna Carby, fertility expert and consultant gynaecologist at Aria Fertility, commented on the news: “We welcome the government’s plans to extend the storage limit for frozen eggs, sperm and embryos. The increase in the number of egg freezing cycles in the UK has risen exponentially over the past few years with improvements in freezing technology and the recent COVID outbreak has led to an additional surge in the numbers of cycles undertaken. Here at Aria, we are delighted that storage limits are set to increase up to 55 years for both eggs and sperm allowing patients the freedom to decide if, and how early, they may choose to freeze.”

Why are storage limits being extended?

The government has taken this step to give prospective parents a greater choice over when they can start a family. Health Secretary Sajid Javid said the current limit was “severely restrictive” and the change will remove the pressure of the “ticking clock in the back of people’s minds”.

Under the current legislation, after the 10-year storage period, parents must decide whether to proceed with fertility treatment at that point or have the cells destroyed. There are some exceptions to this – patients that can prove they are premature infertility, for example, as a result of medical treatment such as chemotherapy, are able to preserve their gametes and embryos for 55 years and the new proposal would allow all fertility patients to be treated equally.

What is egg, sperm or embryo freezing?

During egg freezing, your ovaries are stimulated in the same way as IVF to maximise the number of eggs you reproduce. We monitor your progress and schedule the best time to collect the eggs. Egg collection is a straightforward, minor surgical procedure and we then flash-freeze the suitable eggs in a process known as vitrification.

Before we freeze your sperm, we carry out a fertility assessment including semen analysis. We then receive your instructions on how your sperm can be used in the future. Once the sperm is collected, it is then preserved in liquid nitrogen at very low temperatures to preserve its quality.

Embryo freezing can be performed either as a standalone procedure or after IVF or ICSI to preserve any excess embryos in case you need to undergo further fertility treatments. Your eggs are collected and fertilised like during IVF. They can be frozen when they’re just a single cell, at the two to eight-cell stage or later in their development.

Prevalent research suggests that eggs, sperm and embryos can be stored indefinitely without deteriorating.

The next step is for the plans to be brought before parliament so new legislation can be introduced. Now, all patients with frozen gametes or embryos have been given a two-year extension due to the disruption to fertility treatments caused by the COVID pandemic. For more advice on fertility preservation, get in touch with Aria Fertility to arrange a consultation.

Going through IVF treatment in the workplace can be exhausting and emotionally taxing. There are a lot of appointments you’ll need to attend, and it can be a stressful process.

If you have a full-time job, it can be difficult managing your IVF around it. However, there are some great tips you can follow to make it work. Below, you’ll discover how to successfully manage your IVF treatment in the workplace.

Consider how much time off you will need

To minimise disruption in the workplace, you’ll need to know how much time you need to take off. You can find this out by going over your individual treatment plan with your care team. Figure out how many early morning clinic visits you’ll need to make, alongside how much time off you’ll need after the egg retrieval and embryo transfer procedures.

Speak to your manager

Once you know how much time you’ll need to take off, it’s a good idea to speak to your manager. You can decide how much you want to tell them. If you don’t want to reveal that you are undergoing IVF, you can simply state you have a medical issue. However, you’ll find most managers will be understanding if you are honest about the situation.

Before you speak to them, make sure you have a plan in place. How will you make up any time that is lost? You could also see whether working from home on your appointment days is an option.

Prepare for physical discomfort

Your body goes through some major changes during IVF. Not only will you feel exhausted, but you may experience physical discomfort. It isn’t unusual for women to experience pregnancy symptoms while they are going through the treatment.
To prepare for physical discomfort, wear loose, flattering clothing. Eat smaller meals and snacks if you develop nausea. You’ll also want to limit what you do, so don’t be afraid to pull back on your commitments.

Look after yourself

Going through IVF in the workplace can be stressful. Increased stress levels can wreak havoc on your health. As you are trying to become pregnant, keeping stress levels to a minimum is key. This means you’ll want to make sure you are taking good care of yourself.
Engage in relaxing activities such as reading, yoga, or listening to relaxing music. While it’s hard to practice self-care at work, it isn’t impossible. On your breaks, do something relaxing like going for a walk or reading a good book. Remember to take regular breathing breaks to focus on lowering your stress levels.

If you follow the tips above, you’ll be able to better manage IVF in the workplace. The more you prepare, the easier you’ll find it is to balance IVF with work. For more advice on IVF treatment, call us on 020 3263 6025 or email us at admin@ariafertility.co.uk.

A new study has revealed women who have a BRCA1 gene mutation have fewer eggs than those who don’t. The results of the study, published within the Journal of Clinical Oncology, mean affected women may have a reduced window of opportunity to have children.

Here, we’ll look at what this latest research means, and how it impacts fertility preservation.

Understanding the latest study

The study included a total of 824 women who had undergone BRCA testing. It was revealed that 246 of the women tested positive for either the BRCA1 or BRCA2 mutation. The other 578 tested negative.

The majority of the women were diagnosed with breast cancer. It was discovered that those who did have a BRCA mutation had a 2.04 ng/mL (14.6pmol/l) anti-Müllerian hormone level. Those who didn’t have the mutation had a hormone level of 3.36 ng/mL (24pmol/L).

The results of the study mean women with the BRCA1 mutation may have a shorter reproduction period.

What are BRCA Gene mutations?

BRCA gene mutations are most associated with breast cancer. They are changes within the genes that can lead to illness and genetic disorders. We each have BRCA genes, and they help to release proteins that suppress tumours and fight off cancer. Those with a BRCA gene mutation are therefore at a greater risk of developing the disease.

In terms of fertility, it is now known that a BRCA1 mutation can lead to issues with fertility. With the latest study revealing that it may decrease your reproductive lifespan, those with the gene might want to consider preserving their fertility.

Preserving your fertility

It isn’t known why the BRCA gene mutation impacts fertility. However, it is suspected that the mutated genes can cause the ovaries to have a decreased ovarian reserve. Women with the mutation may be more likely to go through early menopause. Therefore, if you are diagnosed with the gene mutation, you might want to start thinking about protecting your fertility.

Freezing your eggs or embryos is a great option for those worried about losing their fertility. You can talk through your options with a fertility specialist to determine which one is right for you.

Be aware that although BRCA gene mutations can increase your risk of breast and ovarian cancer, it doesn’t mean you’ll definitely get it. However, there is growing evidence that it can impact fertility. Either having a family earlier in life or preserving fertility, should therefore be a consideration for those diagnosed with a mutation.

If you’re worried you may have a BRCA mutated gene, getting tested will help to give you a proper diagnosis. You can then begin to plan for your future. Aria Fertility’s Dr Anna Carby is a senior consultant gynaecologist with a specific interest in fertility preservation and she can advise you on egg or embryo freezing. For more advice on preserving your fertility, call us on 020 3263 6025 or email us at admin@ariafertility.co.uk.

New data published by the UK fertility regulator, the Human Fertilisation and Embryology Authority (HFEA), has found that the IVF success rate is continuing to improve in the UK.

Reviewing the trends in fertility treatment numbers between 1991 and 2019, they were able to ascertain that as well as an increase in IVF success, more single women and same sex couples were seeking fertility treatment.

Chair of the HFEA Julia Chain summarised that there have been “many positive changes in the treatment of patients”, citing “birth rates increasing, multiple birth rates falling and treatment becoming safer”.

A 30-year review of fertility treatment

The report was published to mark the 30-year anniversary of the establishment of the HFEA, the UK’s independent regulator of fertility treatment.

It found that, since 1991, the success rate for all patient groups under the age of 43 for IVF and donor insemination had increased. In patients aged between 35 and 37, this had grown from 6% to 25%.

A common concern about IVF treatment is the possibility of multiple births and its associated complications. The multiple birth rate has dramatically declined, from 28% to just 6% in 2019, reflecting a change in treatment practice.

Sally Cheshire CBE, commented: “Fertility treatment has come a long way over more than 40 years and is now safer whilst helping more people to create their much longed for families.”

“We know that multiple births carry higher risks to mothers and babies and cost more to the NHS. That’s why, it is a great achievement that all our hard work with fertility clinics has paid off as we have now achieved the lowest ever multiple birth rate while continuing to see success rates rise.”

Fertility patient demographics

While patients in heterosexual relationships still account for most fertility treatments, the report also found that the number of single women and same-sex couples choosing to undergo IVF or donor insemination has also rapidly increased in this time frame, reflecting a growing societal attitude change to family creation.

Embryo freezing uptake growing

The report also noted that the use of frozen embryos has gone up by 11% since 2016, which indicates an increased uptake in freeze cycles. Notably, frozen cycles success rates at 23% have overtaken fresh embryo cycles success rates (22%) for the first time since records began, meaning that our patients can be reassured that freezing embryos can give them as much chance of success as using fresh embryos.

For more advice on any of the fertility treatments we offer at Aria, call us on 020 3263 6025 or email us on admin@ariafertility.co.uk. Alternatively, fill in the contact form below and one of our team will be in touch.

Our knowledge of the COVID pandemic and our response – particularly in terms of the vaccines that are now available – is constantly evolving and it’s not surprising that many couples and individuals who are contemplating fertility treatment are feeling unsure about the best course of action.

Studies are now emerging into the effect of both COVID infection and the vaccine on fertility treatment and, so far, the news is good.

COVID and its effect on ovarian reserve

A new study has just been published that found that ovarian reserve was the same or similar after a COVID infection. Although this was a small-scale study, it did reveal promising results for women who are hoping to conceive or about to embark on fertility treatment.

Researchers at a Madrid fertility clinic analysed data from 46 patients undergoing IVF and found that there was little difference in AMH levels before and after a woman become infected with COVID. The results were presented at the European Society of Human Reproduction and Embryology’s annual meeting this June.

The COVID vaccine and its impact on fertility

A study from Wuhan, China, has recently been published in the journal Reproductive Biomedicine Online and analysed data from 237 women of childbearing age. It found that the average sex hormone and AMH concentrations of women who had COVID were no different from women of the same age who didn’t get infected.

In terms of the impact of the vaccine on IVF treatment, a recent Israeli study that investigated the effect of the Pfizer vaccine, identified no differences between IVF cycles taking place before and after the patients received the Pfizer COVID vaccine. Published in Reproductive Biology and Endocrinology, the study analysed the ovarian stimulation cycle and outcome in terms of the number of high-quality embryos produced, both pre- and post-vaccination.

Professor Raoul Orvieto, who led the study at the Sheba Medical Centre, Israel, told the Jerusalem Post, “Comparing two IVF cycles was the best way to see if the vaccine would have any impact in terms of number of eggs or any other factors. It did not.”

It’s important to remember that pregnant women who develop COVID are at risk of becoming seriously unwell and have an increased risk of pregnancy complications, so the current advice is that it’s essential to become vaccinated as soon as you are able.

Click here for more advice on COVID and your fertility treatment or get in touch to discuss this in more detail with our team. Call us on 020 3263 6025 or email us on admin@ariafertility.co.uk or fill in the contact form below.