Preimplantation genetic testing (PGT) allows embryos to be screened for chromosomal abnormalities or specific genetic conditions before transfer.
At Aria Fertility, we offer PGT as part of our IVF programme for patients where it is clinically appropriate, helping to make informed decisions and, for some patients, improving the chance of a successful outcome.
PGT is performed on embryos at the blastocyst stage (day 5). A small number of cells – called a biopsy – are carefully removed from the outer layer of the embryo and analysed. The embryo is frozen while the results are awaited, and only chromosomally normal embryos are transferred in a subsequent FET cycle.
PGT-A (preimplantation genetic testing for aneuploidies) screens embryos for abnormal chromosome numbers. An embryo with the correct number of chromosomes (a euploid embryo) is more likely to implant and less likely to miscarry. PGT-A is most commonly recommended for women over 37, those with recurrent implantation failure, or those with a history of recurrent miscarriage.
PGT-M (preimplantation genetic testing for monogenic conditions): tests for specific inherited single-gene conditions such as cystic fibrosis, BRCA mutations, sickle cell disease or Huntington’s disease.
PGT-SR (preimplantation genetic testing for structural rearrangements): used where one or both partners carry a chromosomal rearrangement, such as a translocation, which can cause recurrent miscarriage or implantation failure.
Your consultant will discuss whether PGT is appropriate for you and explain which type is relevant to your situation.
You undergo a standard IVF cycle. At the blastocyst stage (day 5), a small number of cells from each suitable embryo are biopsied by our skilled embryologists. PGT-M requires pre-cycle preparation with a genetics lab, which typically adds several weeks to the timeline.
Biopsied embryos are frozen immediately using vitrification, while the biopsy samples are sent to the genetics laboratory.
The laboratory analyses the biopsy samples. Results typically take one to two weeks.
Your consultant will discuss the results with you and help you decide which embryo to transfer.
The recommended embryo is transferred in a FET cycle. The preparation and transfer process is the same as for standard FET.
Aria was founded by fertility professionals, which means every decision is driven by what is best for patients. You will have a dedicated consultant overseeing your care, supported by our team of highly experienced embryologists and nurses, to ensure you receive personalised, compassionate care.
Our laboratory was one of the first in the UK to use AI-assisted embryo selection, and our single-embryo transfer rate and multiple-pregnancy rate (currently 3.7%) reflect our commitment to safe, evidence-based care. We are regulated by the Human Fertilisation and Embryology Authority (HFEA) and publish our results transparently.
Our Marylebone clinic offers a calm, unhurried environment and personalised support from the first appointment to the final outcome.
Fertility treatment is a significant financial commitment, and we believe in being transparent about what that means from the outset.
Costs vary depending on your individual treatment plan, the required investigations, and whether additional procedures, such as genetic testing, are recommended. When comparing prices between clinics, it’s worth ensuring you have a full breakdown of all components – consultation fees, monitoring scans, medication, and laboratory costs can vary considerably and are not always included in headline figures.
At Aria, we will discuss the expected costs during your initial consultation and provide you with a fully costed treatment plan before we start, so there are no surprises along the way.
The questions below are intended to give you a clear and honest overview. For advice specific to your situation, we always recommend booking a consultation with one of our team.
What is PGT-A and who should consider it?
PGT-A (preimplantation genetic testing for aneuploidies) screens embryos for chromosomal abnormalities. It is most often recommended for women over 37, those with recurrent implantation failure, those with a history of multiple miscarriages, or those for whom previous cycles have produced embryos of variable quality.
We offer PGT-A at Aria to selected patients for whom it may be beneficial. Testing doesn’t alter or improve the embryo, but in some cases, it can help us choose the most appropriate embryo and avoid subsequent failed cycles.
Does PGT-A improve IVF success rates?
The evidence for PGT-A is nuanced. For certain patient groups – particularly older women and those with recurrent failure – transferring a known euploid embryo can significantly improve the outcome. For younger women with a good prognosis, the benefit is less clear-cut. Your consultant will give you an honest assessment of whether PGT-A is likely to make a meaningful difference in your situation. The HFEA classifies PGT-A as a treatment add-on and notes that, while the evidence is promising, it does not yet meet the threshold for a universal recommendation.
What is the difference between PGT-A and PGT-M?
PGT-A screens embryos for chromosomal number abnormalities. PGT-M tests for a specific inherited single-gene condition known to be carried by one or both parents. PGT-M requires a bespoke test to be developed before the cycle and involves referral to a specialist genetics service.
Does the biopsy harm the embryo?
In experienced hands, embryo biopsy at the blastocyst stage is considered safe. The cells removed are from the outer layer (trophectoderm), the outer layer of cells that will form the placenta and supporting membranes, not the cells that develop into the baby. Studies have not shown increased rates of abnormalities in babies born after PGT biopsy.
What if I only have one or two embryos – is PGT still worth it?
Your consultant will discuss the risks and benefits of biopsying a small cohort honestly, including the risk that biopsy and testing could result in no transferable embryos.
What happens if all my embryos are abnormal?
This can happen, particularly in older patients, and is naturally disappointing. Your consultant will discuss the results with you honestly and explore your options, which may include a further IVF cycle, considering donor eggs, or other paths. We will support you through this conversation.
Can I do PGT on embryos I already have frozen?
In most cases, yes. Frozen blastocysts can be thawed, biopsied and re-frozen. Your consultant can advise on whether this is appropriate for your embryos.
Where is Aria Fertility?
We are located at 8 Welbeck Way, Marylebone, London W1G 9YL – a short walk from Bond Street Underground station. The clinic is deliberately discreet and calm, situated in a quiet mews in the heart of London’s medical district.
When you are ready and the time is right for you, the next step is to contact us, and we will help you arrange a face-to-face, telephone or video-call introduction with one of our consultants.
You can do this by filling in the contact form below or by calling one of our friendly team members on +44 (0) 203 263 6025.
We really look forward to getting to know you and helping guide you toward your next steps toward your dream family.