Embarking on fertility treatment can be overwhelming and stressful, so it helps to be prepared in terms of what to expect during your first fertility consultation and to know what questions you should ask.

Many patients we see at Aria Fertility have undergone treatment on the NHS or at other fertility clinics and so may have already undergone various tests and received a diagnosis. Some are at the start of their fertility journey or wish to learn more about fertility preservation options such as egg freezing. Whatever stage you are at, one of the most important considerations at your first consultation is whether you feel comfortable with your fertility specialist.

Your initial consultation will usually last 30 minutes, and you will be asked about your fertility journey up to this point, as well as in-depth questions on your medical and family history, either as an individual or for both you and your partner if you are attending as a couple.

This first visit will be the opportunity to get to know your fertility doctor and the clinic and for them to get to know you and it is essential you feel comfortable enough to ask questions.

3 questions to ask in your first fertility consultation

  1. What diagnosis might explain why we haven’t been able to conceive?

Your doctor may not be able to tell you the exact cause of infertility at the first visit as we may need to arrange additional testing to help us determine the cause.

However, be aware that potentially one in five cases of fertility cannot be explained. Unexplained infertility is thought to affect 15% to 30% of couples and individuals and is when they have undergone all the appropriate tests and no cause is found. It is most likely to involve issues with egg or sperm quality or problems with the uterus or fallopian tubes that aren’t identifiable during normal fertility testing. Unexplained fertility can still be successfully treated with fertility drugs, IUI and IVF.

  1. What treatments do you recommend for us and what are their potential success rates?

At Aria Fertility we offer several different treatment options. This could be fertility drugs as a standalone treatment or in combination with IUI or IVF. Your fertility doctor will be able to give you information on the success rates of the clinic and advice on how successful a particular treatment option is likely to be, taking into account your age and medical history.

  1. How much does IVF treatment cost?

It can often be embarrassing to ask questions about cost, but fertility treatment is a significant investment. Once a treatment pathway is recommended by our doctors, our Patient Coordinator Team will provide you with a comprehensive breakdown of costs, including any add-ons or medication that have been discussed.

At Aria Fertility, we believe in 360 support. Once you’ve made the informed choice to proceed, our dedicated team, which is composed of your fertility specialist, fertility nurse and patient coordinator, will help you chart the course of your fertility treatment. You will also have the support of a fertility coach who can advise you on nutrition, lifestyle changes, and complementary medicine as a supplement to your medical care.

To arrange a consultation with Aria Fertility, call +44 (0) 203 263 6025.

According to HFEA, the Human Fertilisation and Embryology Authority, cycles of egg freezing have increased tenfold in the UK in the space of a decade, as more and more women start families later in life and look for ways to preserve their fertility.

Now, a large-scale US report on elective fertility preservation outcomes has found that using frozen eggs are a more efficient option than IVF with fresh eggs or embryos at a later age.

The researchers found that 70% of women who froze eggs when they were younger than 38 and then thawed at least 20 eggs later went on to have a baby. In comparison, fewer than 30% of women undergoing IVF at age 40 using fresh eggs became pregnant and fewer than 20% gave birth to live babies.

“Our findings shed light on the factors that track with successful births from egg freezing, which include careful screening of embryos to be thawed and implanted,” says lead author Sarah Druckenmiller Cascante at the department of obstetrics and gynaecology at NYU Langone.

“A better understanding of the live birth rate from egg freezing for age-related fertility decline is necessary to inform patient decision-making.”

Within the study, published in the journal Fertility and Sterility, 543 patients participated with an average age of 38 years old at the time of the first egg freeze, which is older than the generally recommended age to freeze eggs which is 35 years old or younger.

Overall, the study established that 39% of women between 27 and 44 years old, with a majority between 35 and 40 years old at egg freeze, had a least one child from their frozen eggs. Across all ages, women who thawed more than 20 mature eggs had a 58% live birth rate and women under 38 years old who had 20 or more mature eggs thawed achieved a 70% live birth rate per patient.

The study also showed that preimplantation genetic screening with embryos from frozen and eventually thawed eggs resulted in lower miscarriage rates and higher live birth rates per transfer.

The growing popularity of egg freezing

Awareness of fertility preservation is gaining traction in the media with celebrities such as Love Island’s Amy Hart speaking candidly about their decision to freeze eggs. There are many reasons why a woman may choose to delay starting their family, which may include not being in the right place in terms of their relationship or career, or not in a financial position to proceed at this point.

The improvement in the clinical methods used to collect the eggs, assess them for maturity and viability, and then freeze them has also contributed to the success of egg freezing. Previously, the slow freezing process had a survival rate of approximately 30%, but the current method of vitrification means survival rates of over 90% typically.

For more advice on the benefits of egg freezing, call +44 (0) 203 263 6025 to arrange a consultation.

Since the birth of the first baby conceived using in vitro fertilisation in the UK more than four decades ago there have been significant advances, but for many couples IVF remains an emotionally and physically challenging process that may not lead to conception.

Recently, much of the focus has been on the role that Artificial Intelligence (AI) can play in improving the current live birth rate per embryo transferred. This currently stands at 25% and 19% respectively for patients aged 35 to 37 and 38 to 39 according to the most recent figures from HFEA.

“Artificial Intelligence (AI) for gamete and embryo selection has marked the start of a new era in IVF and is here to stay,” explains Xavier Viñals Gonzalez, Aria’s Senior Clinical Embryologist and Laboratory Manager.

“We can now get a deeper level of information which was not available to embryologists before. AI systems are already key for research and development in the field of IVF and will certainly improve our understanding of egg and sperm quality and embryo development.”

AI and IVF

Artificial intelligence describes technology that mimics human cognitive capacity to make predictions based on evolving data. In the IVF lab, it can aid the embryologist to make a rapid and accurate assessment of the health of a gamete or embryo.

Artificial intelligence is used as extension to time lapse monitoring that takes images of embryos at intervals of ten minutes, allowing our embryologists to monitor every stage of embryo development.

AI systems can review a massive amount of data, far more than humans can process, including hundreds of images from each developing embryo. Some AI algorithms are trained to predict clinical pregnancy, others to unveil genetic make-up of the embryos.

By analysing thousands and thousands of these time lapse images and comparing those that go onto successful outcome to those that don’t, AI uses this data to grade the embryos with greatly improved accuracy.

This process is always overseen by our embryologists who review the selection process before implantation but, as Xavier explains, “the assistance of AI systems to daily laboratory workflow will offer patients outcome optimisation and provide better understanding of their chances along reproductive journey.”

A study published last year in the Journal of Assisted Reproduction and Genetics discussed how AI can be used as an essential component in a fertility clinic lab’s quality management system. It could provide “systemic, early detection of adverse outcomes, and identify clinically relevant shifts in pregnancy rates”.

Currently, Aria Laboratories continue to evaluate the efficacy of time-lapse parameters and artificial intelligence algorithms as predictors of embryo potential with the main focus on delivering high success rates to our patients, whilst minimising multiple pregnancy. To learn more about the use of AI in the Aria Fertility lab, call (0) 203 263 6025 to arrange a consultation.

Every June the focus is on male health as Men’s Health Awareness Week campaigns to heighten awareness of preventable health problems and encourage men to choose healthier lifestyle choices.

It’s estimated that male infertility is a factor in 40 to 50% of infertility cases and, in recent years, there has been much research into the crucial role that modifiable lifestyle factors play.

One key lifestyle factor that is known to affect male fertility is being overweight, but the good news is that the damage is reversible. A new study has found that obese men who lose weight – and are able to keep it off – can increase their sperm count by 40%.

Danish researchers studied a group of 47 obese men and their findings were recently published in the journal Human Reproduction. The men were placed on a low-calorie diet for eight weeks and lost on average of 36 lbs. Sperm counts were measured both before and after the diet and discovered a substantial increase in sperm count.

“This study shows that sperm concentration and sperm count were improved after a diet-induced weight loss in men with obesity,” concluded researcher Signe Sørensen Torekov, a professor of biomedical sciences at the University of Copenhagen in Denmark.

The study also revealed the importance of committing to these lifestyle changes – the men were revisited a year later, and half the men had regained the weight, resulting in a corresponding decline in their sperm count.

Other lifestyle factors that could cause male infertility

Obesity can affect hormone levels causing reduced sperm production and concentration and there may also be a link between a raised BMI and both sperm motility and morphology (movement and shape) and DNA damage. However, being overweight isn’t the only lifestyle factor that is known to affect male fertility. Smoking, stress, excessive alcohol consumption, and recreational drugs can all play a role.

Male fertility assessments

The focus of this year’s Male Health Awareness week is the importance of a Man MOT, with guidance on how to check your mental and physical wellbeing and why you should undergo regular health screening checks.

At Aria Fertility, we offer a range of male fertility investigations. The first step is a review of your general health and your medical history. You will then be asked to provide a semen sample and we assess the quality of your sperm, including viscosity, volume, concentration, motility, and morphology. This information is used to advise you of the appropriate fertility treatment plan.

Other tests include those to identify microbes in semen plasma, DNA damage, or sperm maturity.

To book your male fertility assessments, call +44 (0) 203 263 6025.

In vitro fertilisation and other fertility treatments are an often-gruelling process, with a huge impact both physically and emotionally on both men and women. This experience is further compounded for women by discrimination in the workplace, according to a MP who is campaigning for new employee protection for women undergoing IVF.

The Conservative MP for Cities of London and Westminster Nickie Aiken wants to make it illegal for employers to side line or sack women who are trying to conceive through IVF and are having to take time off for fertility-related issues.

Women are facing discrimination at work and even being forced out of their jobs because they haven’t got rights to take IVF treatment currently,” Aiken explains.

“It’s now come to the time that we’ve got to recognise IVF as a very, very important part of reproduction’ she says. “We’ve got an awful birth rate here in this country. We need to keep giving birth to children so that in 30 years’ time, they will be paying taxes, they will be our workers of the future.

“I would also like to see a legal requirement for employers to have a workplace fertility policy. I would like to see organisations introduce guidance on rights to time off work for treatment and miscarriage, flexible working, access to HR support and counselling on a confidential basis. This would help to improve workplace culture for workers looking to build a family through fertility treatment.”

Currently, legal safeguards against pregnancy-related discrimination only begin after implantation has taken place, so women often find themselves having to ‘hide’ the fact that they are undergoing IVF or try and arrange appointments outside of working hours, all of which will have an undeniable effect on stress levels.

Aiken will introduce a private member’s bill at the next parliamentary session to discuss IVF workplace discrimination.

The growth in fertility benefits

Although there is evidently a need to protect many women from IVF discrimination in the workplace, more and more companies are embracing the concept of extending fertility benefits to their employees.

Fertility benefits are proving a powerful way to attract and retain employees. In a survey carried out by Carrot Fertility, the leading global fertility benefits provider for employers, and The National Infertility Association, 88% of employees would even consider changing jobs for access to fertility benefits.

Aria Fertility is delighted to partner with Carrot Fertility to provide fertility care to their UK members.

Nutritional health does play a role in conception and pregnancy, yet there is so much conflicting advice online for those trying for a baby naturally, couples struggling with infertility or individuals experiencing health conditions that affect their fertility.

A fertility dietician can provide clear, personalised nutritional advice with regard to fertility, pregnancy and gynaecological concerns. The benefits can be wide ranging, including:

  • Optimising the chance of conception
  • Helping to regulate ovulation
  • Can improve egg and sperm health
  • May reduce the risk of miscarriage
  • May improve success rate of fertility treatments
  • Reduce pregnancy-related risk factors

Often just the act of focusing on diet can be good for allaying anxiety as the patient can feel they are being proactive at a time when so much is beyond their control.

Alex Ballard Fertility DieticianAlex Ballard (@alextalksdiet), a Band 7 specialist fertility dietitian in the NHS, specialises in preconception nutrition and works with Aria Fertility, helping patients with general enquiries about fertility and nutrition and how that links to fertility treatment or any other health conditions.

“I have been interested in the link between fertility and nutrition since I trained to be a dietician seven years ago as I had family members that were going through fertility treatment and friends that had been recently diagnosed with conditions such as PCOS and endometriosis.”

Unfortunately, it is often challenging to access this support through the NHS. “In seven years of working in the NHS, I have never had a patient referred to me who’s trying to conceive although I know there’s many that would benefit from it.

Support and advice from a fertility nutritionist can be accessed at any point in their journey, but Alex points out that there is optimal time to embark on any changes to lifestyle habits if you’re about to commence fertility treatment.

“If people are motivated then I can help at any stage in their fertility journey but there is a three-month cycle for eggs and sperm to mature to the point that they are ready for fertilisation so any changes you make consistently for 12 weeks or more is likely to have a really beneficial impact both on their fertility and then, hopefully, their pregnancy.”

Patients that could benefit from fertility nutrition advice

 “I see both couples and individuals and have three main types of clients,” fertility dietician Alex explains. “People at the beginning of their fertility journey are often looking for more general advice on a diet that is protective of fertility and foetal development.

“The second type of client has been trying to conceive for a long time and is about to start fertility treatment and wants advice specific for that.

“And, finally, I have many clients who have existing health conditions which are impacting their fertility, and which can be better managed through diet. This includes POCS, endometriosis, coeliac, Crohn’s, diabetes, or nutritional deficiencies.”

How does a fertility dietician work?

Although there is a lot of information available online, Alex finds patients are often overwhelmed and her role is to provide practical advice and workable plans that fit in with modern, busy lives.

“I’m always led by the client. The goal is always realistic, sustainable, and important to them. Just because I think something would be highly beneficial to them, if they don’t agree then it’s not going to be a sustainable change.

“I’m not going to send someone away with a long list of changes for them to implement. It’s more likely to be, let’s make one or two realistic goals and then touch base in a month or so and see how things are going.”

Final advice: variety and moderation are key!

“There are definitely foods that we know are particularly rich in nutrients and good for fertility, but the danger is that you can then fixate on some foods and not get enough of the other nutrients we need. I also advise patients not to be too extreme; never eliminate a specific food group, as every one has a purpose.”

We work closely with a wide range of practitioners to provide support throughout your fertility journey – click here to visit our Support Hub.

The latest UK statistics show that that half of women are now childless at the age of thirty for the first time since records began in the 1920s. A report from the Office for National Statistics (ONS) has found that 50.1% born in 1990 were still child free by their thirtieth. This follows the long-term trend of people opting to have children in later life and a smaller family.

The most common age to have a child is now 31. This is in direct contrast to baby boomers, born in the late 1940s, who were 22 on average when they began their families.

An explosion in opportunities for studying at university and pursuing careers was the catalyst for this trend and modern pressures such as the rising cost of childbearing and job uncertainty are also impacting the decision to start a family. But, at what cost to fertility?

Age affects fertility for both men and women, but in women it is the single biggest factor in determining whether you can conceive and carry a baby successfully. Fertility gradually declines in the 30s, particularly after the age of 35. Even before menopause, the ability to conceive naturally is unlikely by 45.

A woman is born with all the eggs she will ever have; at birth that is approximately 1 million eggs but, during your reproductive lifetime, only 300 to 400 will be ovulated and as you age, your eggs age and the number and quality reduces over time.

The decreased quality increases the chance of miscarriages, ectopic pregnancies and chromosomal abnormalities and raises the pregnancy risks. As you get older, you may also have other medical conditions that could affect your fertility.

Fertility treatment in my 40s: what are my options?

IVF treatment with PGT-A: For women in their late 30s and 40s that wish to undergo fertility treatment with their own eggs, we recommend screening all suitable embryos which have reached the blastocyst stage of development (day 5 embryo) using pre-implantation genetic testing for aneuploidy (chromosomal errors).

State-of-the-art embryo selection technology: Time-lapse imaging continuously monitors the development of the embryo and uses artificial intelligence, based on their developmental pattern, to identify the embryos which have the highest chance of implantation in the uterus.

Egg donation: Increasingly, egg donation is becoming a more effective way of overcoming age-related infertility. An egg donor may be anonymous or known to you and egg donation treatment is very similar to a standard approach to IVF, expect you will not be required to undergo the ovarian stimulation phase of the treatment.

If you are over 40 and would like to understand more about your own fertility, the first step would be to arrange a consultation to meet with one of our Aria consultants.

This month is Stress Awareness Month which has been held every April for the last thirty years, yet events over the last two years have made this event even more essential. Anxieties over COVID and the impact of lockdowns have all taken a toll on our mental health. Multiple studies have shown a major increase in the number of adults reporting symptoms of anxiety, depression, and insomnia.

For those undergoing IVF, however, this has been an even more stressful time, with cancelled appointments, delayed procedures and worries about how the pandemic would impact their fertility treatment. We take a look at where stress, diet and fertility intersect.

Stress and the body

There are many factors that are stressful for mind and body – external pressures such as your job or family responsibilities and internal influences such as our diet or how body is functioning.

Stress affects our body in a myriad of ways: it increases blood pressure levels, spikes our blood sugar, releases stress hormones, and speeds up our heart as we enter a flight or fight response. The problem is that the pressure of modern-day living means we’re continually in a state of full alert.

Diet and fertility stress

A well-balanced diet can help us combat the physiological changes caused by stress. Much of the focus is on stabilising our blood sugar levels.

Prioritising protein: when the body is chronically stressed, it demands protein as that slows down release of sugar into the blood stream and the best sources are lean meat, fish, eggs, beans, pulses, nuts and seeds.

Time your intake: eating regular, well-balanced meals are the key to maintaining energy levels and your mood while staving off tiredness.

Fight the easy fix: highly refined foods such as white bread, pasta, sweets, cereals, as well many tinned or processed products, are full of added, hidden sugars that cause a spike in blood sugar levels.

Avoid emotional eating: try not to reach for food when you’re feeling stressed as it diverts blood flow away from your digestive system and it will probably just leave you feeling bloated and uncomfortable.

Alex Ballard Fertility DieticianAlex Ballard (@alextalksdiet), a Band 7 specialist fertility dietitian in the NHS, specialises in preconception nutrition and works with Aria Fertility, helping patients with general enquiries about fertility and nutrition and how that links to fertility treatment or any other health conditions

“A Mediterranean diet is specifically good for mood; one with oily fish, lots of fruit and veg, nuts and seeds, and whole grains. But I find that just the act of focusing on diet and taking control can also be good for allaying anxiety as the patient is being proactive about improving their own health.”

We work closely with a wide range of practitioners to provide support throughout your fertility journey – click here to visit our Support Hub.

At Aria Fertility Clinic, we recognise the importance of supporting your emotional, mental, and physical wellbeing during your fertility journey. Acupuncture is increasingly popular as a complementary therapy for those undergoing fertility treatment or managing hormonal conditions.

Acupuncture is an ancient tenet of traditional Chinese medicine whereby very fine needles are placed at strategic points on the head and body to release the flow of energy or chi. It is believed to be beneficial in the treatment of a wide range of health conditions, including fertility issues, by correcting energy imbalances in the body.

How does acupuncture aid in fertility treatment

Acupuncture can be used by both men and women during the fertility process. For men, it may prove beneficial when going through ICSI treatment. For women, it’s thought to have several benefits:

  • Increasing blood flow: acupuncture can boost blood circulation to the ovaries and uterus
  • Regulating hormones: acupuncture can improve menstrual regularity, restore ovulation patterns, and regulate the release of key hormones including follicle stimulating hormones. This can be highly beneficial for women suffering from PCOS
  • Reducing stress: acupuncture releases the body’s endorphins which helps to relax patients undergoing fertility treatment. Patients often report they feel more ‘in control’ and proactive

Emma Cannon fertility and women’s health expertEmma Cannon, a fertility and women’s health expert, is a registered acupuncturist and works with men and women who wish to optimise natural conception or support IVF.

“Most of the research into acupuncture and IVF has been focused on the pre- and post-embryo transfer stage,” Emma explains. “Clearly that’s because when you design a study everyone must be at the same stage to produce comparable data. The studies showed promising results, but they never went beyond it. So, I’m more interested in what acupuncture can do outside of embryo transfer.

“We use it for women whose endometrium has previously not reached the correct thickness and I might combine acupuncture with a nutritional programme. That can be very effective.”

Emma pointed to another area where they have had good results. “It can be common during an IVF cycle that the follicles do not evenly develop. By improving the blood flow to ovarian arteries, it can improve follicle development and help the other ovary catch up.”

In recent years, several studies have attempted to evaluate the benefit of acupuncture in alleviating infertility or as an adjunct to IVF or ICSI and while we have no conclusive evidence yet, a growing body of scientific research supports its efficacy as a complementary therapy.

What is indisputable, though, is that acupuncture has no adverse effects and anecdotally our patients report that it has been highly beneficial in relieving stress during their fertility journey.

To get in touch with Emma, please visit her website. For more information on the practitioners we work with, please visit our Support Hub.

The IVF laboratory is a key component to the beating heart of any fertility clinic – it is here where human fertilisation occurs, sparking the creation of embryos and the beginning of life.

With the perfect integration of three highly specialised areas (andrology, embryology and preimplantation genetics), Aria provides a focused and individualised approached to optimising the IVF laboratory environment and managing the most complex of infertility issues.

Led by Laboratory Manager, Xavier Vinals Gonzalez, the scientific team has enhanced embryology processes to deliver high success rates, with a constant focus on patient care and experience as core to the laboratory values.

Digitalised environment

We understand how important it is for us to be able to deliver the best results possible. In doing so, laboratory activities we recognise the importance of an environment with minimised carbon footprint. We recognise the synergies and benefits which can be derived from a fully digitalised environment, such as electronic witnessing (traceability) which eliminates the risk of errors.

Digital traceability is incorporated across each specific stage of the IVF pathway:

Taking sperm processing as an example, conventional preparations have 14 associated steps and 32 failure modes – potential risks to a sample or errors in the process, such as sample mismatch and impairment of sperm function. In Aria’s digital ecosystem, each stage in the process is associated with an electronic tag containing three identifiers for each sample allowing for full traceability. Furthermore, electronic data gets routinely checked in order to test and improve the workflow and efficiency in the laboratory.

Integrating new technologies

IVF is a constantly evolving field, which requires continuous careful assessment of emerging solutions by doctors and scientists. In order to evaluate the incorporation of innovations into the laboratory, a systematic decision strategy which accounts for effectiveness and risk is always followed.

Last year, Aria cryostorage facilities was the first clinic worldwide to introduce a novel monitoring technology. With the aid of such equipment, Francisca Mora, ESHRE certified clinical Embryologist at Aria, developed a study analysing cryokinetic variables, which helped to validate the integrity and lifetime of cryostorage tanks adding a unique high-security level and cryosurveillance to our stored samples.

Aria’s Laboratories have always welcomed advances in the field of IVF, where technology can bring standardisation and precision while enhancing normal functions of eggs, sperm and embryos. Based on the use of microfluidic devices for sperm preparation, embryologist Kimberley Hill, showed a reduced operational risk and improved laboratory workflow. Such devices use the natural properties of sperm to ‘swim up’ (rheotaxis), whilst reducing the associated steps in the process.

Currently, Aria Laboratories continue to evaluate the efficacy of non-invasive genetic testing, time-lapse parameters and artificial intelligence algorithms as predictors of embryo potential with the main focus on delivering high success rates to our patients, whilst minimising multiple pregnancy.

Rigorous quality control

Correct functioning of equipment is imperative for maintaining the functions of eggs, sperm and embryos. Temperature, gas and humidity sensors are distributed along the equipment in the laboratory and monitored 24/7. Should any anomaly be detected, different sensors will trigger an alarm and inform the Embryology Team, which can connect remotely and troubleshoot rapidly.

This digital surveillance system is tested against our weekly manual quality control checks to ensure correct performance. Annually, Aria Laboratories have a planned shut-down where all pieces of equipment are analysed, calibrated and tested; providing us with the reassurance our equipment is functional and we continue to offer a premium quality service with the best results.

Research and development

The importance of research and development activities is well embedded in our daily work and philosophy. Journal clubs and quality review meetings are organised between departments to track new practices and developments in the field. It is key for us to be able to provide an individualised and exceptional experience to our patients, which requires managing each case independently.

Within the embryology department, Miriam Alvarez’s interest resides in reviewing literature and research with a goal of potential adaptation of the laboratory procedures for cases of autoimmune disorders to maximise the chances of success when embarking on the IVF journey.

Aria Laboratories are proud to be able to provide an excellent and evidence-based approach to infertility cases, which would not be possible without the cohesive integration with the clinical, nursing & patient support teams.

To find out more about our work, call +44 (0) 203 263 6025 to arrange a consultation.