What is PICSI?

Physiological intracytoplasmic sperm injection (PICSI) is a technique used to select sperm to use in Intracytoplasmic sperm injection (ICSI) treatment. It involves placing sperm with hyaluronic acid (HA), a natural compound found in the body. PICSI identifies sperm that can bind to HA and these sperm are selected for use in treatment.

Risks of PICSI

PICSI is a non-invasive procedure performed on a semen sample as an additional step in the ICSI process. Risks associated with the use of ICSI also apply to PICSI; there are no significant additional risks to the patient or embryo.


Seven studies including a large RCT called HabSelect form the main published evidence. The six studies prior to HabSelect suggested no benefit to P-ICSI.

HabSelect was published in 2019 and included more than 2,700 patients needing ICSI. It showed no significant difference between P-ICSI and ICSI in terms of live birth. However it can’t rule out a small (2 to 3%) increased benefit in P-ICSI through a reduction in miscarriage. However to prove this a study would require in excess of 20,000 participants.

Current HFEA grading

For more information, please visit the HFEA website

Your next step.

When you are ready and the time is right for you, the next step is to contact us and we will help you arrange a face-to-face, telephone or video-call introduction with one of our consultants.

You can do this by filling in the contact form below or by giving one of our friendly team a call on +44 (0) 203 263 6025 or emailing us at admin@ariafertility.co.uk.